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Rock legend Ozzy Osbourne died on Tuesday at 76 after battling a uncommon type of Parkinson’s disease.
The Black Sabbath lead singer had been open about his situation for the final a number of years, first discussing it throughout an look on ABC’s “Good Morning America” in 2019.
He and spouse Sharon Osbourne revealed the rock star’s diagnosis of PRKN-2, a genetic situation usually outlined as early-onset Parkinson’s illness that evolves extra slowly.
“I am no good with secrets and techniques,” the singer mentioned. “I can’t stroll round with it anymore, ‘trigger it is like, I am operating out of excuses, you already know?”
Osbourne confirmed with GMA that he had a “dangerous fall” that led to neck surgical procedure and interference together with his nerves.
Singer Ozzy Osbourne performs through the NFL recreation between the Buffalo Payments and the Los Angeles Rams on Sept. 8, 2022, at SoFi Stadium in Inglewood, California. Osbourne died on Tuesday at 76 after battling a uncommon type of Parkinson’s illness. (Brian Rothmuller/Icon Sportswire through Getty Photos)
The rocker took a while off from performing to deal with his well being issues, however simply weeks before his death, he took to the stage one final time for Black Sabbath’s “Again to the Starting” efficiency on July 5 in Birmingham, England.
What causes Parkinson’s?
Dr. Brandon Crawford, a developmental functional neurologist in Cedar Park, Texas, and co-founder of the NeuroSolution Middle of Austin, famous that Parkinson’s illness can have an effect on everybody in a different way.
The progressive neurodegenerative dysfunction impacts the world of the mind known as the midbrain, which produces the chemical dopamine.
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Dopamine is thought for selling happiness, nevertheless it additionally motivates the physique to maneuver and assume.
Solely about 10% to fifteen% of Parkinson’s circumstances are “clearly linked” to genetics, Crawford famous, whereas the bulk is because of a mixture of gentle genetic susceptibility and environmental triggers.
Parkinson’s is a progressive neurodegenerative dysfunction that impacts the world of the mind known as the midbrain, which produces the neurotransmitter dopamine. (iStock)
“Issues like toxins, head trauma, sleep disruption or power irritation tip the stability towards illness,” Crawford, who didn’t deal with Osbourne, instructed Fox Information Digital.
Parkinson’s sufferers usually discover a bodily slowing and incapacity to maneuver their physique. Some will first expertise tremors, which Crawford known as a “hallmark signal,” typically starting within the fingers.
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The illness may trigger digestive complications, reminiscent of constipation, infected intestine or basic intestinal points. Cognitive decline can also be a “main element” in Parkinson’s growth, the physician famous.
“Dopamine travels from the midbrain into the frontal lobe, and it offers us our skill to assume,” Crawford mentioned. “It offers us a number of our government expertise. And in order that cognitive skill begins to say no.”
Flowers, notes and floral tributes positioned on the Black Sabbath Bridge bench are seen in Birmingham, U.Okay., on July 24, 2025, in reminiscence of Ozzy Osbourne. (Ioannis Alexopoulos/Anadolu through Getty Photos)
Sufferers might also discover gradual speech and dysregulated moods, typically exhibiting signs of depression or basic lack of motivation.
“It is past simply having tremors or slowed motion,” Crawford mentioned. “This neurodegenerative illness actually begins to impression somebody’s complete life.”
Illness administration
Whereas there isn’t a treatment for Parkinson’s, it may be managed with dopamine agonists (drugs that mimic dopamine) and different stimulants that may stabilize signs for a restricted time.
There could also be “moments of readability” and higher motion, Crawford mentioned, “however then as these medication begin to wane, every little thing form of comes crashing again.”
Ozzy Osbourne and Sharon Osbourne attend the Pre-GRAMMY Gala on January 25, 2020, in Beverly Hills, California. Sharon Osbourne described her husband’s situation throughout a 2019 interview with GMA, explaining how a number of good days are adopted by “a very dangerous day.” (Alberto E. Rodriguez/Getty Photos for The Recording Academy)
Sharon Osbourne described her husband’s situation through the interview with GMA, explaining how a number of good days have been typically adopted by “a very dangerous day.”
In 2024, throughout an episode of his SiriusXM present “Ozzy Speaks,” with co-host Billy Morrison, the singer shared particulars about stem cell treatments for his situation, which he’d reportedly been receiving for a number of years.
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Kelly Osbourne, Ozzy’s daughter, commented in a 2020 interview with Cells4Life, a U.Okay.-based stem cell financial institution, that her father’s progress after only one remedy was “mind-blowing.”
“He desires to rise up. He desires to do issues. He desires to be part of the world once more,” she mentioned. “He’s strolling higher. He’s speaking higher. His signs are lessening. He’s constructing the muscle power again that he wants.”
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Stem cell remedy for Parkinson’s illness may substitute the dopamine neurons misplaced to degeneration, in keeping with Mass Normal Brigham.
The hospital system introduced FDA approval of a Section 1 medical trial for the remedy in March.
Environmental components
Ozzy Osbourne’s heavy-metal, rock-star way of life almost certainly didn’t assist the event of his situation, in keeping with Crawford.
Circadian disruptions is usually a main precursor of Parkinson’s, as staying up late into the night time in synthetic lighting and consuming meals exterior of a standard schedule could be detrimental to the brain.
Ozzy Osbourne’s heavy-metal, rock-star way of life almost certainly didn’t assist the event of his situation, in keeping with a physician. (Getty Photos)
“When the solar goes down, our retinas, our mind, our complete biology, is just not designed to have this high-frequency mild stimulus,” he instructed Fox Information Digital. “A number of research present that one of these publicity … can disrupt this circadian biology.”
These components may alter the microbiome, intestine operate, neurotransmitter manufacturing, liver operate, detox pathways and stem cell migration, and may promote power irritation, the physician warned.
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For somebody like Ozzy Osbourne who lived a way of life that almost certainly doesn’t take into account “pure rhythms,” there is usually a larger threat of different situations, like Alzheimer’s or coronary heart illness, in keeping with the knowledgeable.
Different way of life components that would have led to Osbourne’s Parkinson’s analysis embody the fixed presence of loud music, substance abuse and head-banging, Crawford talked about.
Ozzy Osbourne performs on stage with Jake E. Lee. Way of life components that would have led to Osbourne’s Parkinson’s analysis embody the fixed presence of loud music, substance abuse and head-banging, a physician mentioned. (Phil Dent/Redferns; Getty Photos)
“That’s going to create some repeated head trauma … if you are going to be up there continuously shaking this mind in your head that is actually like a bowl filled with jelly,” he mentioned.
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Along with loud music, research have proven that long-term publicity to heavy metals in a rock star’s surroundings — like mercury, manganese and lead — may result in an elevated threat of Parkinson’s.
“As you are touring the world, you are staying in older venues or utilizing outdated gear in a poorly ventilated space,” Crawford mentioned. “All of these items begin to add up.”