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Comic Amy Schumer, 44, has just lately come clear about her wrestle with Cushing’s syndrome, resulting in a dramatic weight reduction.
Schumer’s transformation has sparked dialog on-line, to which she responded in a now-deleted Instagram submit that shut down hypothesis about cosmetic enhancements.
“I didn’t lose 30lbs — I misplaced 50,” she emphasised on social media, including that she doesn’t get Botox or filler.
AMY SCHUMER DROPPED 50 POUNDS TO BATTLE DISEASE THAT ‘CAN KILL YOU’ IF UNTREATED
Schumer doubled down that her weight loss was not about her look, however about staying alive.
“To not look scorching, which does really feel enjoyable and momentary,” she mentioned. “I did it to outlive. I had a illness that makes your face extraordinarily puffy that may kill you, however the web caught it and that illness has cleared.”
Amy Schumer attends Selection’s 2024 Energy of Ladies: New York occasion on Might 2, 2024, in New York Metropolis on the left. On the best, Schumer later poses for a photograph posted to Instagram after her weight reduction. (Marleen Moise/WireImage; Amy Schumer/Instagram)
“Sorry for no matter feeling it’s supplying you with that I misplaced that weight,” she added. “I’ve had cosmetic surgery through the years and I exploit [Mounjaro]. Sorry to anybody they let down. I’m ache free. I can [play] tag with my son.”
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The actress additionally addressed her shifting hormones, saying that she’s “completely happy to share extra if anybody has any questions on how I’m wanting or feeling or the place I’m in my perimenopause process.”
“I didn’t lose 30lbs — I misplaced 50,” Schumer emphasised on social media, including that she doesn’t get Botox or filler. (Amy Schumer/Instagram)
What’s Cushing’s syndrome?
Schumer beforehand revealed that she had been identified with Cushing’s syndrome, a hormonal dysfunction that may trigger excessive swelling, fatigue and probably deadly issues.
Dr. Peter Balazs, a hormone and weight reduction specialist in New Jersey, offered extra particulars on the situation in an interview with Fox Information Digital.
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“Cushing’s syndrome is attributable to extended, excessive publicity to cortisol, which is your physique’s fundamental stress hormone,” he mentioned. “Normally, the surplus cortisol is a results of extended steroid use. We see this many occasions with sufferers who’ve some autoimmune dysfunction.”
Balazs mentioned the “key” to Cushing’s syndrome isn’t just weight gain, however a “particular redistribution” of fats attributable to an excessive amount of cortisol.
Amy Schumer is photographed throughout a visitor interview on The Tonight Present Starring Jimmy Fallon on Feb. 13, 2024 (left), and later seen strolling by means of midtown New York Metropolis on Oct. 28, 2025 (proper). (Todd Owyoung/NBC by way of Getty Photos; Raymond Corridor/GC Photos/Getty Photos)
Fats could also be pushed to the stomach, chest, higher again (known as a “buffalo hump”) or face, typically thought of “moon face,” the physician mentioned.
Cortisol additionally breaks down protein, which results in a thinning within the legs and arms. “Weight acquire may be robust, involuntary and onerous to handle,” Balazs added.
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Cortisol stimulates “starvation facilities” within the mind, raises blood sugar and promotes fats storage, particularly deep stomach fats, in accordance with the physician.
Cushing’s syndrome can even trigger high blood pressure, bone loss and typically sort 2 diabetes, per Mayo Clinic.
Along with weight acquire in sure areas, different signs might embrace pink or purple stretch marks on the abdomen, hips, thighs, breasts and underarms, in addition to zits, gradual wound therapeutic, and skinny, frail pores and skin that bruises simply.
With Cushing’s syndrome, fats might accumulate within the stomach, chest, face or higher again (known as a “buffalo hump”). (iStock)
Ladies with Cushing’s syndrome typically expertise thick, darkish hair on the face and physique, in addition to irregular intervals. Signs amongst males can embrace a decrease intercourse drive, lowered fertility and erectile dysfunction.
Mayo Clinic listed different potential signs, together with extreme fatigue, muscle weak spot, despair, nervousness, irritability, temper swings, bother with focus and reminiscence, headache, sleeplessness, pores and skin darkening and stunted progress in youngsters.
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These with signs ought to contact their physician instantly, particularly if they’re taking steroids to deal with well being points like bronchial asthma, arthritis or inflammatory bowel illness, as these medicines can exacerbate the situation.
The Mayo Clinic has reported that the “sooner remedy begins, the higher the probabilities for restoration.”
“I’ve had cosmetic surgery through the years and I exploit [Mounjaro],” Schumer said in a social media submit. (George Frey/Bloomberg)
For sufferers like Schumer, weight reduction is often not the principle objective, Balazs famous, however it’s a “vital signal” of successful treatment.
“The first objective is to normalize your excessive cortisol ranges,” he mentioned. “I consider Amy Schumer received handled first for her underlying drawback. As soon as the cortisol is normalized, which is a very powerful step, there’s a job to make use of adjunct medicines to lower weight.”
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Amongst GLP-1s, Mounjaro is an “glorious option to lower deep stomach fats and increase insulin sensitivity of cells,” Balazs added.
Fox Information Digital’s Stephanie Giang-Paunon contributed to this report.
Fox Information Digital reached out to Schumer’s rep requesting remark.