FDA approves first GLP-1 pill for weight loss
Fox Information senior medical analyst Dr. Marc Siegel joins ‘America’s Newsroom’ to debate the approval of a GLP-1 tablet for weight reduction and compares it to injection-based alternate options.
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Celebrities have been striving for well being in 2025, with many dropping important quantities of weight — in lots of circumstances with the assistance of GLP-1 drugs like Ozempic.
Under are 4 A-list stars who shared their weight-loss journeys this yr, with or with out the assistance of pharmaceuticals.
No. 1: Oprah Winfrey
Lengthy-time discuss present host Oprah Winfrey was not too long ago featured in an unique interview with Folks Journal, throughout which she mentioned her weight reduction and her new e book, “Sufficient: Your Well being, Your Weight and What It’s Prefer to Be Free.”
Winfrey, 71, started taking a GLP-1 medication in 2023 however tried to stop simply six months in to see if she may drop a few pounds with out it. No matter her eating regimen and train routines, the media mogul mentioned she nonetheless gained again 20 kilos after stopping the drug.
Oprah Winfrey is pictured in February 2020 (left) and in October 2025 (proper). (Steve Jennings/Getty Photographs; Lanna Apisukh/WWD through Getty Photographs)
“It may be a lifetime factor,” she shared. “I am on hypertension remedy, and if I’m going off the high blood pressure remedy, my blood stress goes to go up. The identical factor is true now, I notice, with these drugs. I’ve confirmed to myself [that] I would like it.”
Winfrey revealed that her default weight, at 211 kilos, was not wholesome, as she was pre-diabetic and had excessive ldl cholesterol.
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The creator instructed Folks that she injects a GLP-1 weekly, and has additionally paid out of pocket for buddies who couldn’t afford the drug.
Winfrey added that the absence of meals noise “has given me a quiet power that comes with every thing I do. The whole lot is simply calmer and stronger.”
Amy Schumer, Meghan Trainor and Oprah Winfrey (left to proper) are among the many celebrities who’ve revealed their weight reduction in 2025. (Raymond Corridor/GC Photographs; Chris Haston/WBTV through Getty Photographs; Theo Wargo/Getty Photographs)
No matter GLP-1 entry or tolerance, Winfrey inspired these struggling with obesity that it’s “not your fault.”
“I need folks to cease blaming [themselves] for genes and an setting [they] can’t management,” she mentioned. “I need folks to have the data, no matter you select to do with it, whether or not you get the drugs, or whether or not you need to hold weight-reduction plan.”
No. 2: Amy Schumer
Comedian Amy Schumer dropped 50 kilos after being identified with Cushing’s syndrome, a hormonal dysfunction that may trigger excessive swelling, fatigue and probably deadly problems.
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Schumer’s transformation sparked dialog on-line, to which she responded in a now-deleted Instagram submit that shut down hypothesis about cosmetic enhancements.
“I didn’t lose 30 lbs — I misplaced 50,” she emphasised on social media, including that she doesn’t get Botox or filler.
Amy Schumer is pictured in Might 2024 at left, and on the precise after her weight reduction in 2025. (Marleen Moise/WireImage; Amy Schumer/Instagram)
Schumer doubled down that her weight reduction was not about her look, however about staying alive. She additionally confirmed that she has used the GLP-1 remedy Mounjaro.
“To not look scorching, which does really feel enjoyable and momentary,” she mentioned. “I did it to outlive. I had a illness that makes your face extraordinarily puffy that may kill you, however the web caught it and that illness has cleared.”
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“Sorry for no matter feeling it’s providing you with that I misplaced that weight,” she added. “I’ve had plastic surgery over time and I exploit [Mounjaro] … I’m pain-free. I can [play] tag with my son.”
The actress additionally addressed her shifting hormones, saying that she’s “completely satisfied to share extra if anybody has any questions on how I’m wanting or feeling or the place I’m in my perimenopause course of.”
No. 3: Meghan Trainor
“All About That Bass” singer Meghan Trainor has additionally confronted haters for “body-shaming” her after a dramatic 60-pound weight reduction.
MEGHAN TRAINOR BLASTS BODY SHAMERS WHO ‘ATTACK’ HER AFTER 60-POUND WEIGHT LOSS
Trainor not too long ago instructed “Leisure Tonight” that she’s “by no means felt higher” and is taking care of her health for the primary time since having her two youngsters.
Meghan Trainor confirmed off her dramatic weight reduction on the Baby2Baby Gala in November 2025. (Emma McIntyre/Getty Photographs for SiriusXM; Michael Kovac/Getty Photographs for Baby2Baby)
“I really feel nice, and that’s when folks assault me,” she mentioned, noting that the criticism is just getting “louder” and “meaner.” Regardless of the net noise, Trainor emphasised that she’s targeted on her well-being.
“I’m taking good care of myself,” she reiterated. “I’ve to discover a strategy to not be affected by that.”
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The singer’s well being journey started by eliminating gluten and dairy from her eating regimen after discovering out that she had a “leaky intestine.” The artist additionally obtained severe about strength training.
Trainor’s personal health coach, Bella Maher of Malibu Our bodies, posted before-and-after photographs of the pop star on Instagram, revealing how exhausting she labored earlier than introducing a GLP-1 drug.
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“Watching her remodel from the within out has been some of the significant elements of my work,” the caption reads. “She did a lot of this on her personal earlier than ever introducing a GLP-1, and even after beginning it, the remedy was merely a help, not the explanation for her outcomes. GLP-1s is usually a highly effective device, however they’re actually not a change plan. SHE is the explanation this labored.”
No. 4: Lizzo
Singer and musician Lizzo stepped out this yr with a slimmer determine, as the general public speculated about her GLP-1 use.
Throughout a dialogue about Ozempic on Trisha Paytas’ “Simply Trish” podcast in June, the musician shared that she had “tried every thing” for weight reduction.
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“Ozempic works since you eat less food,” she mentioned. “It makes you are feeling full. So, in case you can simply do this by yourself and get thoughts over matter, it is the identical.”
Lizzo is pictured in March 2021 (left) and in March 2025 (proper). (Jay L. Clendenin/Los Angeles Occasions through Getty Photographs; Karwai Tang/WireImage)
Lizzo shared that ending her vegan eating regimen and consuming extra meat helped her persist with a caloric deficit, since she as soon as consumed “a number of faux meat,” bread and rice.
“And I needed to eat a number of it to remain full … I used to be consuming 3,000 to five,000 energy a day.”
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“For me, once I began consuming complete meals, like beef and hen and fish, I used to be truly full and never increasing my abdomen by placing a number of … faux issues in there that weren’t truly filling me up,” she added.
The Grammy winner revealed that her largest inspiration for shedding weight was to alleviate the extreme back pain she would really feel after acting on stage.
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“My physique was hurting,” she mentioned. “I need to be Tina Turner. I need to be doing stadium exhibits once I’m 70. If my again is on this observe proper now, there’s no means.”
Fox Information Digital’s Stephanie Giang-Paunon contributed to this report.