Fentanyl has made headlines for driving overdose deaths, however the Facilities for Illness Management and Prevention (CDC) is warning of the rise of an even deadlier drug.
Final yr, practically 70% of all U.S. overdose deaths have been attributed to illegally manufactured fentanyls (IMFs). A type of was carfentanil, an altered model of fentanyl that’s stated to be 100 occasions stronger, the CDC warned in a Dec. 5 alert.
Deaths from carfentanil rose by greater than 700% prior to now yr, in line with the identical supply — there have been 29 lethal overdoses between January and June 2023, and 238 in that very same timeframe in 2024.
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This knowledge got here from the CDC’s State Unintentional Drug Overdose Reporting System (SUDORS).
The numbers may truly be greater, because the 2024 knowledge is preliminary and never all overdose deaths have been reported, the company famous.

Carfentanil, an altered model of fentanyl that’s stated to be 100 occasions stronger, the CDC warned in a Dec. 5 alert. (iStock)
Since an outbreak of carfentanil-linked deaths in 2016 and 2016, the drug had “largely disappeared” till this latest reemergence, the CDC famous.
Based mostly on the rise in deadly overdoses, the CDC is looking for “rigorous monitoring” of carfentanil and different opioids stronger than fentanyl.
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As with different illicit medication, its “excessive profitability” seemingly drives its prevalence, in line with Dr. Chris Tuell, medical director of dependancy providers on the University of Cincinnati Faculty of Medication.
“Very small quantities can produce hundreds of doses,” he advised Fox Information Digital.
“Synthetic opioids like carfentanil are comparatively simple to fabricate in illicit labs,” Tuell went on. “For the reason that drug is an artificial, it’s simpler to supply — in contrast to heroin, which depends on a plant like opium.”
Why is carfentanil so harmful?
Carfentanil is 10,000 extra occasions stronger than morphine and 100 occasions stronger than fentanyl, Tuell confirmed.
“Even a small quantity could be deadly, as it may trigger respiratory failure,” he stated.

Carfentanil can typically be within the type of “pressed tablets” that resemble prescription medicines, the knowledgeable stated. (iStock)
One of many main issues with carfentanil and fentanyl is that they’re ceaselessly combined with different medication, reminiscent of benzodiazepines, cocaine and opioids, which might result in unintended overdoses, in line with Tuell.
“Carfentanil may also resemble cocaine and heroin, so it blends proper in with the opposite medication,” he warned.
“Even a small quantity could be deadly, as it may trigger respiratory failure.”
“Even a tiny quantity can improve the efficiency of a drug combination, resulting in a stronger and longer-lasting excessive.”
Carfentanil usually appeals to drug customers who’ve a excessive tolerance to opioids as a result of they search a stronger substance, “making the drug enticing regardless of the chance,” Tuell famous.
How is the drug administered?
Carfentanil could be injected and is ceaselessly combined with different opioids or heroin, Tuell stated. In a powder type, it may be inhaled.
“Inhaling the drug could be rapidly dangerous as a result of it may enter the bloodstream, leading to an overdose,” Tuell warned. “This will occur deliberately or by chance, because the drug can turn out to be simply airborne.”

Carfentanil could be injected and is ceaselessly combined with different opioids or heroin, an dependancy specialist warned. (iStock)
Carfentanil can typically be within the type of “pressed tablets” that resemble prescription medicines, the knowledgeable stated.
“Carfentanil could be deadly on the 2-milligram vary relying on the route of administration,” he cautioned.
What mother and father ought to know
“Kids are actually the era of artificial intelligence and deepfakes, as illicit medication are posing like common prescription medicines,” Tuell cautioned.
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To assist protect kids from the risks of illicit medication, the knowledgeable emphasised the significance of open communication and training.
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“Educate your youngster concerning the risks and dangers of drug use, together with artificial opioids like carfentanil,” he suggested.
Dad and mom ought to present monitoring and supervision of their youngsters, concentrate on their social circles and restrict unsupervised on-line actions, Tuell beneficial.

Based mostly on the rise in deadly overdoses, the CDC is looking for “rigorous monitoring” of carfentanil and different opioids stronger than fentanyl. (iStock)
“I additionally imagine it is necessary that oldsters notice that 84% of people with a substance use dysfunction even have a co-occurring mental health subject,” he added.
“Looking for out psychological well being providers in your youngster may assist handle the underlying points that will have led to a substance use dysfunction.”
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The CDC known as for particular efforts in stopping deaths from illegally manufactured fentanyls, “reminiscent of sustaining and enhancing distribution of danger discount instruments, growing entry to and retention of remedy for substance use issues, and stopping drug use initiation.”
Fox Information Digital reached out to the Drug Enforcement Administration (DEA) for remark.